Minnesota Hospital Association

Quality & Patient Safety

Clostridioides difficile infection

Clostridioides difficile infection (CDI) is becoming more prevalent as a health care-associated infection. CDI causes diarrhea that can progress to colitis, colon perforation and sepsis. According to the Centers for Disease Control and Prevention (CDC), CDI is fatal for approximately 14,000 individuals each year.   

MHA has developed a CDI road map outlining evidence-based recommendations and standards for the development of prevention and quality improvement programs that align process improvements with outcome data. Road maps reflect published literature and guidance from relevant professional organizations and regulatory agencies, as well as identified proven practices. MHA’s Healthcare-Associated Infections (HAI) Committee provides expert guidance and oversight to all health care-associated infection road maps.   

MHA’s CDI road map comprises a succinct approach to the prevention of health care facility transmission of CDI through surveillance, early recognition and appropriate testing, isolation precautions, environmental cleaning, and promotion of antimicrobial stewardship.

MHA members can log in to the website at the top-right corner of this page to view the CDI road map. 

CDI toolkits

CDI environmental cleaning training and supervision toolkit


CDI environmental cleaning in the OR and the ED toolkit


Evaluation tools

  • Evaluation of Clostridiodies difficile Testing and Ordering Practices (PDF)
  • Clostridiodies difficile Infection (CDI) Case Review Tool (PDF)
  • CDI TAP Strategy Implementation Packet (PDF)


Patient education


CDI hand hygiene toolkit